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Free estradiol and testosterone were calculated with a validated algorithm based on derived equations. The Mann—Whitney rank-sum test was used for nonnormally distributed data. Importantly, we observed that orchiectomy was associated with less liver steatosis and insulin sensitivity, despite cross-sex hormone treatment. Find articles by Francisco J. Author Disclosure Statement No competing financial interests exist. The Endocrine Society cross-sex hormonal therapy guidelines suggest antiandrogen therapy combined with oral or transdermal estrogens to induce feminization for transwomen. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels.

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Transwomen and the Metabolic Syndrome: Is Orchiectomy Protective?

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Likewise, Zheng et al. Importantly, transwomen with the highest levels of testosterone also tended to have the highest hepatic steatosis Fig. The major novel findings were: Find articles by Eric Vilain. Measurement of intracellular triglyceride stores by H spectroscopy: Moreover, the four transwomen with the highest testosterone levels High T group also had the lowest levels of estradiol Fig.

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Noel Bairey Merz , 1 and Deborah J. Introduction The United States has an estimated 8—16 million people 0. To define differences between these three groups, a one-way analysis of variance was used. The procedure for the DHEAS and cortisol assays is a solid-phase, competitive, chemiluminescent enzyme immunoassay. Adiposity Subcutaneous and visceral adiposity was determined from an axial abdominal image between the vertebral L2 and L3 bodies. Measurement of intracellular triglyceride stores by H spectroscopy:

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